InnateDB Protein
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IDBP-136691.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Vcl
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Protein Name
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vinculin
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Synonyms
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9430097D22; AA571387; AI462105; AW545629;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022369
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InnateDB Gene
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IDBG-136687 (Vcl)
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Protein Structure
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Function |
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. Co-localizes with LIMD1 in the focal adhesions (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 141 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
141 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98927
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InterPro |
IPR006077
Vinculin/alpha-catenin
IPR017997
Vinculin
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PFAM |
PF01044
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PRINTS |
PR00806
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q64727
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PhosphoSite |
PhosphoSite-Q64727
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22330
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UniGene |
Mm.279361
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RefSeq |
NP_033528
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MGI ID |
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MGI Symbol |
Vcl
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OMIM |
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CCDS |
CCDS26860
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HPRD |
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IMGT |
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EMBL |
AK035184
AK077850
BC008520
BC008554
L13299
L13300
L18880
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GenPept |
AAA40557
AAB96843
AAH08520
AAH08554
BAC28973
BAC37033
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