InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd36

Summary

InnateDB Protein

IDBP-136840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd36

Protein Name

CD36 antigen

Synonyms

FAT; GPIV; Scarb3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080974

InnateDB Gene

IDBG-136838 (Cd36)

Protein Structure

UniProt Annotation

Function

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport (By similarity). Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005515	protein binding
GO:0008035	high-density lipoprotein particle binding
GO:0008289	lipid binding
GO:0030169	low-density lipoprotein particle binding
GO:0070892	lipoteichoic acid receptor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002221	pattern recognition receptor signaling pathway
GO:0006898	receptor-mediated endocytosis
GO:0006910	phagocytosis, recognition
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0010629	negative regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010886	positive regulation of cholesterol storage
GO:0015911	plasma membrane long-chain fatty acid transport
GO:0019915	lipid storage
GO:0019934	cGMP-mediated signaling
GO:0030194	positive regulation of blood coagulation
GO:0030301	cholesterol transport
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034381	plasma lipoprotein particle clearance
GO:0034383	low-density lipoprotein particle clearance
GO:0035634	response to stilbenoid
GO:0042953	lipoprotein transport
GO:0042992	negative regulation of transcription factor import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277	apoptotic cell clearance
GO:0043410	positive regulation of MAPK cascade
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0044130	negative regulation of growth of symbiont in host
GO:0044539	long-chain fatty acid import
GO:0045087	innate immune response (InnateDB)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050830	defense response to Gram-positive bacterium
GO:0055096	low-density lipoprotein particle mediated signaling
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0060907	positive regulation of macrophage cytokine production
GO:0071221	cellular response to bacterial lipopeptide
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid
GO:0071447	cellular response to hydroperoxide
GO:2000121	regulation of removal of superoxide radicals
GO:2000334	positive regulation of blood microparticle formation
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft