Version 5.4
Mus musculus Protein: Spag6
Summary
InnateDB Protein IDBP-137398.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spag6
Protein Name sperm associated antigen 6
Synonyms PF16;
Species Mus musculus
Ensembl Protein ENSMUSP00000023468
InnateDB Gene IDBG-137396 (Spag6)
Protein Structure
UniProt Annotation
Function Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. {ECO:0000269PubMed:10684790, ECO:0000269PubMed:12167721}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:10684790}. Cell projection, cilium, flagellum {ECO:0000269PubMed:10684790}. Note=Associated with microtubules. Detected on the sperm flagellum.
Disease Associations Note=Defects in Spag6 are a cause of hydrocephalus and of male infertility.
Tissue Specificity Highly expressed in testis. Not detected in prostate, ovary, spleen, thymus, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:10684790, ECO:0000269PubMed:12391165}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0044183 protein binding involved in protein folding
Biological Process
GO:0007283 spermatogenesis
GO:0030030 cell projection organization
GO:0030317 sperm motility
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005929 cilium
Protein Structure and Domains
PDB ID MGI:1354388
InterPro IPR000225 Armadillo
IPR000357 HEAT
IPR016024 Armadillo-type fold
IPR019538 26S proteasome non-ATPase regulatory subunit 5
PFAM PF00514
PF02985
PF10508
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JLI7
PhosphoSite PhosphoSite-
TrEMBL Q497N2
UniProt Splice Variant
Entrez Gene 50525
UniGene Mm.399278
RefSeq NP_056588
MGI ID
MGI Symbol Spag6
OMIM
CCDS CCDS27988
HPRD
IMGT
EMBL AF173866 AF486266 AK005732 BC090660 BC100455 CH466521
GenPept AAF35831 AAH90660 AAI00456 AAM64149 BAB24211 EDK97426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca