Version 5.4
Homo sapiens Protein: POLR2M
Summary
InnateDB Protein IDBP-13766.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2M
Protein Name glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000299638
InnateDB Gene IDBG-545520 (POLR2M)
Protein Structure
UniProt Annotation
Function Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269PubMed:16769904}.
Subcellular Localization Isoform 1: Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis. {ECO:0000269PubMed:15233991}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0032774 RNA biosynthetic process
GO:0051685 maintenance of ER location
Cellular Component
GO:0005635 nuclear envelope
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0CAP2
PhosphoSite PhosphoSite-P0CAP2
TrEMBL E9PP13
UniProt Splice Variant
Entrez Gene 81488
UniGene Hs.702937
RefSeq NP_056347
HUGO HGNC:14862
OMIM 606485
CCDS CCDS32252
HPRD 07575
IMGT
EMBL AC025271 AC090651 AF326773 AK074767 AK074955 AK128618 AL050091 AY207007 AY353061 BC001510 CH471082
GenPept AAH01510 AAK92284 AAO39707 AAQ76837 BAC11193 BAC11313 BAC87533 CAB43263 EAW77525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca