InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcf21

Summary

InnateDB Protein

IDBP-137799.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcf21

Protein Name

transcription factor 21

Synonyms

bHLHa23; capsulin; epc; epicardin; Pod-1; Pod1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053178

InnateDB Gene

IDBG-137797 (Tcf21)

Protein Structure

UniProt Annotation

Function

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1. {ECO:0000269PubMed:10944221}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Expressed at high levels in lung, kidney, gut, heart, ovary and podocytes (visceral glomerular epithelial cells). Also found in spleen, large intestine, uterus, bladder and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0046983	protein dimerization activity
GO:0050681	androgen receptor binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001763	morphogenesis of a branching structure
GO:0001822	kidney development
GO:0001944	vasculature development
GO:0006351	transcription, DNA-templated
GO:0007530	sex determination
GO:0007548	sex differentiation
GO:0009887	organ morphogenesis
GO:0014707	branchiomeric skeletal muscle development
GO:0030855	epithelial cell differentiation
GO:0031063	regulation of histone deacetylation
GO:0032835	glomerulus development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048286	lung alveolus development
GO:0048536	spleen development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048608	reproductive structure development
GO:0048732	gland development
GO:0060008	Sertoli cell differentiation
GO:0060021	palate development
GO:0060425	lung morphogenesis
GO:0060426	lung vasculature development
GO:0060435	bronchiole development
GO:0060539	diaphragm development
GO:0060541	respiratory system development
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0072162	metanephric mesenchymal cell differentiation
GO:0072277	metanephric glomerular capillary formation