InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPX4

Summary

InnateDB Protein

IDBP-13828.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPX4

Protein Name

glutathione peroxidase 4 (phospholipid hydroperoxidase)

Synonyms

GPx-4; GSHPx-4; MCSP; PHGPx; snGPx; snPHGPx;

Species

Homo sapiens

Ensembl Protein

ENSP00000346103

InnateDB Gene

IDBG-13826 (GPX4)

Protein Structure

UniProt Annotation

Function

Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform Mitochondrial: Mitochondrion.Isoform Cytoplasmic: Cytoplasm.

Disease Associations

Tissue Specificity

Present primarily in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity
GO:0008430	selenium binding
GO:0043295	glutathione binding
GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity

Biological Process

GO:0006325	chromatin organization
GO:0006644	phospholipid metabolic process
GO:0006749	glutathione metabolic process
GO:0006979	response to oxidative stress
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007568	aging
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0032355	response to estradiol
GO:0042744	hydrogen peroxide catabolic process
GO:0044281	small molecule metabolic process
GO:0050727	regulation of inflammatory response
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome