Version 5.4
Mus musculus Protein: Serpind1
Summary
InnateDB Protein IDBP-138821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpind1
Protein Name serine (or cysteine) peptidase inhibitor, clade D, member 1
Synonyms AA985900; AI303446; Hcf2; HCII;
Species Mus musculus
Ensembl Protein ENSMUSP00000023450
InnateDB Gene IDBG-138819 (Serpind1)
Protein Structure
UniProt Annotation
Function Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed predominantly in liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008201 heparin binding
Biological Process
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:96051
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49182
PhosphoSite PhosphoSite-P49182
TrEMBL
UniProt Splice Variant
Entrez Gene 15160
UniGene Mm.6609
RefSeq NP_032249
MGI ID
MGI Symbol Serpind1
OMIM
CCDS CCDS28000
HPRD
IMGT
EMBL BC034543 U07425
GenPept AAA18452 AAH34543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca