Version 5.4
Mus musculus Protein: Acot13
Summary
InnateDB Protein IDBP-139055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acot13
Protein Name acyl-CoA thioesterase 13
Synonyms 0610006O17Rik; Them2;
Species Mus musculus
Ensembl Protein ENSMUSP00000006900
InnateDB Gene IDBG-139053 (Acot13)
Protein Structure
UniProt Annotation
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis. {ECO:0000269PubMed:19405909, ECO:0000269PubMed:24072708}.
Subcellular Localization Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin (PubMed:17045243). {ECO:0000269PubMed:17045243}.
Disease Associations
Tissue Specificity Highly expressed in the kidney and moderately in the heart, liver, brain, small and large intestine. Also expressed in brown adipose tissue. {ECO:0000269PubMed:17045243, ECO:0000269PubMed:17704541, ECO:0000269PubMed:19405909, ECO:0000269PubMed:22345407}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0047617 acyl-CoA hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1914084
InterPro IPR003736 Phenylacetic acid degradation-related domain
IPR006683 Thioesterase superfamily
IPR029069 HotDog domain
PFAM PF03061
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQR4
PhosphoSite PhosphoSite-Q9CQR4
TrEMBL Q4VA32
UniProt Splice Variant
Entrez Gene 66834
UniGene
RefSeq NP_080066
MGI ID 2CY9
MGI Symbol Acot13
OMIM
CCDS CCDS26380
HPRD
IMGT
EMBL AK002261 AK008624 AK144523 BC018165 BC096567 CH466561
GenPept AAH18165 AAH96567 BAB21973 BAB25786 BAE25924 EDL32477 EDL32478

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca