InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Limk2

Summary

InnateDB Protein

IDBP-139231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Limk2

Protein Name

LIM motif-containing protein kinase 2

Synonyms

Limk-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099162

InnateDB Gene

IDBG-139221 (Limk2)

Protein Structure

UniProt Annotation

Function

Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Isoform 3 is testis specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007283	spermatogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005801	cis-Golgi network

Protein Structure and Domains

PDB ID

MGI:1197517

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001478 PDZ domain
IPR001781 Zinc finger, LIM-type
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00595
PF13180
PF00412

PRINTS

PR00109

PIRSF

SMART

SM00228
SM00132
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt