InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ssc5d

Summary

InnateDB Protein

IDBP-139378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ssc5d

Protein Name

RIKEN cDNA A430110N23 gene

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052126

InnateDB Gene

IDBG-139376 (Ssc5d)

Protein Structure

UniProt Annotation

Function

Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces. {ECO:0000269PubMed:21217009}.

Subcellular Localization

Secreted {ECO:0000269PubMed:21217009}. Cytoplasm {ECO:0000269PubMed:21217009}.

Disease Associations

Tissue Specificity

Detected throughout the gastrointestinal and genitourinary tracts, in serosal salivary gland, the exocrine part of pancreas and testis, as well as in a few tubular structures in kidney. Not detected in lung and heart (at protein level). Strongly expressed in testis, kidney and pancreas, with lower levels detected in bone marrow, spleen, lung, liver, colon, stomach and skeletal muscle. Very low levels or no expression detected in thymus, esophagus, jejunum, ileum, duodenum, ovary, uterus, heart, trachea, brain, cerebellum and bladder. {ECO:0000269PubMed:21217009}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0043236	laminin binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006952	defense response
GO:0007275	multicellular organismal development
GO:0042494	detection of bacterial lipoprotein
GO:0045087	innate immune response
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:2000482	regulation of interleukin-8 secretion
GO:2000483	negative regulation of interleukin-8 secretion