Version 5.4
Mus musculus Protein: Srp54c
Summary
InnateDB Protein IDBP-140055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srp54c
Protein Name signal recognition particle 54B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021407
InnateDB Gene IDBG-140541 (Srp54c)
Protein Structure
UniProt Annotation
Function Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).
Subcellular Localization Nucleus speckle {ECO:0000250}. Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006184 GTP catabolic process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
Cellular Component
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0016607 nuclear speck
GO:0048500 signal recognition particle
Protein Structure and Domains
PDB ID MGI:1346087
InterPro IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain
IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR003495 CobW/HypB/UreG domain
IPR003593 AAA+ ATPase domain
IPR004125 Signal recognition particle, SRP54 subunit, M-domain
IPR006325 Signal recognition particle, SRP54 subunit, eukaryotic
IPR013822 Signal recognition particle, SRP54 subunit, helical bundle
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029007 MobB-type P-loop domain
PFAM PF00448
PF01656
PF02492
PF02978
PF02881
PF03205
PRINTS
PIRSF
SMART SM00962
SM00382
SM00963
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P14576
PhosphoSite PhosphoSite-P14576
TrEMBL
UniProt Splice Variant
Entrez Gene 665155
UniGene
RefSeq NP_036029
MGI ID 1WGW
MGI Symbol Srp54a
OMIM
CCDS CCDS36449
HPRD
IMGT
EMBL AK010716 AK011928 AK136033 BC019683 X16319
GenPept AAH19683 BAB27138 BAB27921 BAE22786 CAA34386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca