InnateDB Protein
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IDBP-141102.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Peg3
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Protein Name
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paternally expressed 3
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Synonyms
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AL022617; ASF-1; End4; Gcap4; mKIAA0287; Pw1; Zfp102;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000050750
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InnateDB Gene
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IDBG-141100 (Peg3)
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Protein Structure
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Function |
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth. {ECO:0000269PubMed:10195900, ECO:0000269PubMed:10681424, ECO:0000269PubMed:11943780, ECO:0000269PubMed:9500555}.
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Subcellular Localization |
Nucleus. Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Brain, glial cells, neurons, skeletal muscle, uterus and placenta. In the placenta it found in all trophoblast cells. {ECO:0000269PubMed:11260267, ECO:0000269PubMed:11331620, ECO:0000269PubMed:8563758, ECO:0000269PubMed:8806818}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104748
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q3URU2
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PhosphoSite |
PhosphoSite-Q3URU2
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TrEMBL |
Q0P5Y8
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UniProt Splice Variant |
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Entrez Gene |
18616
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UniGene |
Mm.473952
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RefSeq |
NP_032843
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MGI ID |
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MGI Symbol |
Peg3
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OMIM |
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CCDS |
CCDS20783
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HPRD |
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IMGT |
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EMBL |
AB003040
AF038939
AF105264
AF105265
AF105266
AK122238
AK141217
AK163845
BC048778
BC072661
BC085183
BC089344
U48804
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GenPept |
AAB96922
AAC52770
AAF16868
AAH48778
AAH72661
AAH85183
AAH89344
BAB85589
BAC65520
BAE24595
BAE37516
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