InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tut1

Summary

InnateDB Protein

IDBP-142151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tut1

Protein Name

terminal uridylyl transferase 1, U6 snRNA-specific

Synonyms

2700038E08Rik; PAPD2; Rbm21; TUTase6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093958

InnateDB Gene

IDBG-142149 (Tut1)

Protein Structure

UniProt Annotation

Function

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication- dependent histone mRNA degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0004652	polynucleotide adenylyltransferase activity
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding
GO:0050265	RNA uridylyltransferase activity