InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lif

Summary

InnateDB Protein

IDBP-142321.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Lif

Protein Name

leukemia inhibitory factor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036853

InnateDB Gene

IDBG-142317 (Lif)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001135	RNA polymerase II transcription factor recruiting transcription factor activity
GO:0005125	cytokine activity
GO:0005146	leukemia inhibitory factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001974	blood vessel remodeling
GO:0006366	transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0007566	embryo implantation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0019827	stem cell maintenance
GO:0030324	lung development
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410	positive regulation of MAPK cascade
GO:0045595	regulation of cell differentiation
GO:0045651	positive regulation of macrophage differentiation
GO:0045835	negative regulation of meiosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046697	decidualization
GO:0046888	negative regulation of hormone secretion
GO:0048286	lung alveolus development
GO:0048644	muscle organ morphogenesis
GO:0048666	neuron development
GO:0048711	positive regulation of astrocyte differentiation
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0048863	stem cell differentiation
GO:0060135	maternal process involved in female pregnancy
GO:0060426	lung vasculature development
GO:0060463	lung lobe morphogenesis
GO:0060707	trophoblast giant cell differentiation
GO:0060708	spongiotrophoblast differentiation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation
GO:1900182	positive regulation of protein localization to nucleus
GO:1901676	positive regulation of histone H3-K27 acetylation