InnateDB Protein
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IDBP-142663.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ccrn4l
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Protein Name
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CCR4 carbon catabolite repression 4-like (S. cerevisiae)
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Synonyms
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AU043840; Ccr4; nocturnin;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023849
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InnateDB Gene
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IDBG-142661 (Ccrn4l)
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Protein Structure
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Function |
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos. {ECO:0000269PubMed:17400819, ECO:0000269PubMed:20498072, ECO:0000269PubMed:20685873, ECO:0000269PubMed:21820310, ECO:0000269PubMed:22073225, ECO:0000269PubMed:22082366, ECO:0000269PubMed:22331129, ECO:0000269PubMed:23449310}.
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Subcellular Localization |
Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the differentiated adipocyte (at protein level). Ubiquitous. {ECO:0000269PubMed:10521507, ECO:0000269PubMed:11394964, ECO:0000269PubMed:20392228}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:109382
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InterPro |
IPR005135
Endonuclease/exonuclease/phosphatase
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PFAM |
PF03372
PF14529
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O35710
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PhosphoSite |
PhosphoSite-O35710
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TrEMBL |
B2RTJ8
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UniProt Splice Variant |
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Entrez Gene |
12457
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UniGene |
Mm.86541
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RefSeq |
NP_033964
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MGI ID |
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MGI Symbol |
Ccrn4l
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OMIM |
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CCDS |
CCDS17336
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HPRD |
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IMGT |
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EMBL |
AF183960
AF199491
AK087790
BC139369
BC139370
CH466530
U70139
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GenPept |
AAB62717
AAD56547
AAG01384
AAI39370
AAI39371
BAC40004
EDL35194
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