InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNRPD1

Summary

InnateDB Protein

IDBP-1428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRPD1

Protein Name

small nuclear ribonucleoprotein D1 polypeptide 16kDa

Synonyms

HsT2456; Sm-D1; SMD1; SNRPD;

Species

Homo sapiens

Ensembl Protein

ENSP00000300413

InnateDB Gene

IDBG-1426 (SNRPD1)

Protein Structure

UniProt Annotation

Function

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. {ECO:0000269PubMed:18984161, ECO:0000269PubMed:23333303}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:18984161}. Nucleus {ECO:0000269PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.

Experimentally validated
Total	136 [view]
Protein-Protein	135 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0000387	spliceosomal snRNP assembly
GO:0000398	mRNA splicing, via spliceosome
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0034660	ncRNA metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005685	U1 snRNP
GO:0005687	U4 snRNP
GO:0005689	U12-type spliceosomal complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030532	small nuclear ribonucleoprotein complex
GO:0034709	methylosome
GO:0034715	pICln-Sm protein complex
GO:0034719	SMN-Sm protein complex
GO:0071013	catalytic step 2 spliceosome