InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mgarp

Summary

InnateDB Protein

IDBP-142881.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgarp

Protein Name

RIKEN cDNA 4930583H14 gene

Synonyms

4930583H14Rik; AI195347; CESP-1; HUMMR; Osap; Qsap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040703

InnateDB Gene

IDBG-142879 (Mgarp)

Protein Structure

UniProt Annotation

Function

Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology. {ECO:0000269PubMed:19325000, ECO:0000269PubMed:19528298}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion. Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion.

Disease Associations

Tissue Specificity

Expressed in the ovary, testis, brain, adrenal glands and the compartments of the visual nervous system. Expressed in corneal endothelium (CE) (at protein level). Expressed in steroidogenic tissues with the highest level of expression observed in the adrenal gland. Weakly expressed in placenta. Weakly expressed in astrocytes and neurons under normoxia. Strongly expressed in astrocytes and neurons under hypoxia. Expressed in each layer of the retina, with particularly higher staining in the inner segment of the photoreceptor (IS), the outer plexiform layer (OPL) and the ganglion cell layer (GCL). {ECO:0000269PubMed:16565373, ECO:0000269PubMed:19325000, ECO:0000269PubMed:19528298, ECO:0000269PubMed:20107910, ECO:0000269PubMed:21447634}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0008089	anterograde axon cargo transport
GO:0008090	retrograde axon cargo transport
GO:0010822	positive regulation of mitochondrion organization
GO:0019896	axon transport of mitochondrion
GO:0071383	cellular response to steroid hormone stimulus
GO:0071456	cellular response to hypoxia
GO:0097211	cellular response to gonadotropin-releasing hormone