Version 5.4
Mus musculus Protein: Serpinb6a
Summary
InnateDB Protein IDBP-143453.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Serpinb6a
Protein Name serine (or cysteine) peptidase inhibitor, clade B, member 6c
Synonyms 4930482L21Rik; D330015H01Rik; ovalbumin; PI-6; Serpinb6; Spi3;
Species Mus musculus
Ensembl Protein ENSMUSP00000075848
InnateDB Gene IDBG-143524 (Serpinb6a)
Protein Structure
UniProt Annotation
Function Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. {ECO:0000269PubMed:17761692}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17761692, ECO:0000269PubMed:20451170}.
Disease Associations
Tissue Specificity Expressed in the inner ear hair cells, keratinocytes of hair follicles and epidermis in abdominal skin. {ECO:0000269PubMed:17761692, ECO:0000269PubMed:20451170}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0008406 gonad development
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:103123
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60854
PhosphoSite PhosphoSite-Q60854
TrEMBL Q4FJQ6
UniProt Splice Variant
Entrez Gene 20719
UniGene Mm.252210
RefSeq NP_001230121
MGI ID 1M37
MGI Symbol Serpinb6a
OMIM
CCDS CCDS26441
HPRD
IMGT
EMBL AC161117 AC161461 AK167295 AK169145 AL450406 BC006766 BC057950 CH466546 CT010346 U25844
GenPept AAA79684 AAH06766 AAH57950 BAE39400 BAE40924 CAJ18554 EDL40870 EDL40872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca