InnateDB Protein
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IDBP-143584.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Trmt12
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Protein Name
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tRNA methyltranferase 12 homolog (S. cerevisiae)
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Synonyms
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4632406N01Rik; AI449275; Tyw2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000047831
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InnateDB Gene
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IDBG-143582 (Trmt12)
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Protein Structure
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Function |
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha- carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915510
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InterPro |
IPR003402
tRNA transferase Trm5/Tyw2
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF02475
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BG71
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PhosphoSite |
PhosphoSite-Q8BG71
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68260
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UniGene |
Mm.278805
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RefSeq |
NP_080918
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MGI ID |
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MGI Symbol |
Trmt12
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OMIM |
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CCDS |
CCDS37081
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HPRD |
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IMGT |
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EMBL |
AK019481
AK031429
AK076857
AK079291
BC052533
BC055850
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GenPept |
AAH52533
AAH55850
BAB31750
BAC27399
BAC36508
BAC37597
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