InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dpysl3

Summary

InnateDB Protein

IDBP-143788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpysl3

Protein Name

dihydropyrimidinase-like 3

Synonyms

CRMP-4; DRP-3; TUC4; Ulip; ULIP-1; Ulip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025379

InnateDB Gene

IDBG-143786 (Dpysl3)

Protein Structure

UniProt Annotation

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0017124	SH3 domain binding
GO:0035374	chondroitin sulfate binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0006208	pyrimidine nucleobase catabolic process
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0030336	negative regulation of cell migration
GO:0048666	neuron development
GO:0048678	response to axon injury
GO:0051017	actin filament bundle assembly
GO:0051260	protein homooligomerization
GO:0051491	positive regulation of filopodium assembly
GO:0051764	actin crosslink formation
GO:0071345	cellular response to cytokine stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030027	lamellipodium
GO:0030426	growth cone
GO:0031941	filamentous actin
GO:0044297	cell body
GO:0070382	exocytic vesicle