Version 5.4
Mus musculus Protein: Bphl
Summary
InnateDB Protein IDBP-143842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bphl
Protein Name biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)
Synonyms 2010012D11Rik; 5730533B08Rik; AI115341;
Species Mus musculus
Ensembl Protein ENSMUSP00000046168
InnateDB Gene IDBG-143840 (Bphl)
Protein Structure
UniProt Annotation
Function Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1915271
InterPro IPR000073 Alpha/beta hydrolase fold-1
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00561
PF00326
PRINTS PR00111
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R164
PhosphoSite PhosphoSite-Q8R164
TrEMBL Q3TDN8
UniProt Splice Variant
Entrez Gene 68021
UniGene Mm.140243
RefSeq NP_080788
MGI ID
MGI Symbol Bphl
OMIM
CCDS CCDS49229
HPRD
IMGT
EMBL AK002907 AK078232 AK152712 AK170099 BC023146 BC025162
GenPept AAH23146 AAH25162 BAB22447 BAC37185 BAE31438 BAE41563

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca