InnateDB Protein
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IDBP-144428.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Postn
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Protein Name
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periostin, osteoblast specific factor
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Synonyms
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A630052E07Rik; AI747096; OSF-2; Osf2; peri; PLF; PN;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000080276
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InnateDB Gene
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IDBG-144426 (Postn)
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Protein Structure
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Function |
Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX. {ECO:0000269PubMed:10404027, ECO:0000269PubMed:20181949}.
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Subcellular Localization |
Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.
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Disease Associations |
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Tissue Specificity |
Preferentially expressed in periosteum and periodontal ligament. Also expressed in the developing and adult heart. {ECO:0000269PubMed:10404027, ECO:0000269PubMed:11335131}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1926321
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InterPro |
IPR000782
FAS1 domain
IPR011489
EMI domain
IPR016666
TGF beta-induced protein bIGH3/osteoblast-specific factor 2
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PFAM |
PF02469
PF07546
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PRINTS |
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PIRSF |
PIRSF016553
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SMART |
SM00554
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TIGRFAMs |
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Modification |
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SwissProt |
Q62009
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
50706
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UniGene |
Mm.402268
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RefSeq |
XP_006501716
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MGI ID |
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MGI Symbol |
Postn
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK030756
BC031449
D13664
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GenPept |
AAH31449
BAA02835
BAC27122
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