InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tceb2

Summary

InnateDB Protein

IDBP-144555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tceb2

Protein Name

transcription elongation factor B (SIII), polypeptide 2

Synonyms

0610040H15Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066210

InnateDB Gene

IDBG-144553 (Tceb2)

Protein Structure

UniProt Annotation

Function

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	87 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016567	protein ubiquitination

Cellular Component

GO:0031462	Cul2-RING ubiquitin ligase complex
GO:0031466	Cul5-RING ubiquitin ligase complex
GO:0070062	extracellular vesicular exosome
GO:0070449	elongin complex