InnateDB Protein
|
IDBP-144747.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Xbp1
|
Protein Name
|
X-box binding protein 1
|
Synonyms
|
D11Ertd39e; TREB-5; TREB5; XBP-1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000054852
|
InnateDB Gene
|
IDBG-144745 (Xbp1)
|
Protein Structure
|
|
Function |
Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE) (By similarity). Isoform 2 is involved in controlling the production of interleukin-6. {ECO:0000250, ECO:0000269PubMed:12612580, ECO:0000269PubMed:14559994}.
|
Subcellular Localization |
Nucleus.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
18 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000981
|
sequence-specific DNA binding RNA polymerase II transcription factor activity
|
GO:0001085
|
RNA polymerase II transcription factor binding
|
GO:0003677
|
DNA binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0043565
|
sequence-specific DNA binding
|
|
Biological Process |
GO:0002070
|
epithelial cell maturation
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0006366
|
transcription from RNA polymerase II promoter
|
GO:0030968
|
endoplasmic reticulum unfolded protein response
|
GO:0031017
|
exocrine pancreas development
|
GO:0042493
|
response to drug
|
GO:0042593
|
glucose homeostasis
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0051602
|
response to electrical stimulus
|
GO:0060096
|
serotonin secretion, neurotransmission
|
GO:0060691
|
epithelial cell maturation involved in salivary gland development
|
GO:0071236
|
cellular response to antibiotic
|
GO:1900103
|
positive regulation of endoplasmic reticulum unfolded protein response
|
GO:1901800
|
positive regulation of proteasomal protein catabolic process
|
|
Cellular Component |
|
PDB ID |
MGI:98970
|
InterPro |
IPR004827
Basic-leucine zipper domain
IPR008917
Transcription factor, Skn-1-like, DNA-binding domain
|
PFAM |
PF00170
PF07716
|
PRINTS |
|
PIRSF |
|
SMART |
SM00338
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O35426
|
PhosphoSite |
PhosphoSite-O35426
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
22433
|
UniGene |
|
RefSeq |
NP_038870
|
MGI ID |
|
MGI Symbol |
Xbp1
|
OMIM |
|
CCDS |
CCDS24400
|
HPRD |
|
IMGT |
|
EMBL |
AB036745
AF027963
AF443192
AL662876
BC008153
BC029197
|
GenPept |
AAB81862
AAH08153
AAH29197
AAL60202
BAB13793
CAI24935
|
|
|