InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAMK2B

Summary

InnateDB Protein

IDBP-14507.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK2B

Protein Name

calcium/calmodulin-dependent protein kinase II beta

Synonyms

CAM2; CAMK2; CAMKB;

Species

Homo sapiens

Ensembl Protein

ENSP00000351542

InnateDB Gene

IDBG-14499 (CAMK2B)

Protein Structure

UniProt Annotation

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. {ECO:0000269PubMed:16690701}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:21529938}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000269PubMed:21529938}; Peripheral membrane protein {ECO:0000269PubMed:21529938}; Cytoplasmic side {ECO:0000269PubMed:21529938}. Note=In slow- twitch muscle, evenly distributed between longitudinal SR and junctional SR.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. {ECO:0000269PubMed:16690701}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0010976	positive regulation of neuron projection development
GO:0014733	regulation of skeletal muscle adaptation
GO:0019221	cytokine-mediated signaling pathway
GO:0046777	protein autophosphorylation
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0051823	regulation of synapse structural plasticity
GO:0051924	regulation of calcium ion transport
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060998	regulation of dendritic spine development
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0090129	positive regulation of synapse maturation

Cellular Component

GO:0005654	nucleoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030666	endocytic vesicle membrane
GO:0033017	sarcoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF08332

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt