InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thap1

Summary

InnateDB Protein

IDBP-145275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thap1

Protein Name

THAP domain containing, apoptosis associated protein 1

Synonyms

4833431A01Rik; AW490810;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042464

InnateDB Gene

IDBG-145273 (Thap1)

Protein Structure

UniProt Annotation

Function

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest levels in heart, liver and kidney. Lower levels in brain and lung. {ECO:0000269PubMed:20200153}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001935	endothelial cell proliferation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0007346	regulation of mitotic cell cycle