InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v0c

Summary

InnateDB Protein

IDBP-145386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0c

Protein Name

ATPase, H+ transporting, lysosomal V0 subunit C

Synonyms

Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16; VATL; Vma3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024932

InnateDB Gene

IDBG-145384 (Atp6v0c)

Protein Structure

UniProt Annotation

Function

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Vacuole membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0007035	vacuolar acidification
GO:0007042	lysosomal lumen acidification
GO:0015991	ATP hydrolysis coupled proton transport
GO:0030177	positive regulation of Wnt signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0016021	integral component of membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0070062	extracellular vesicular exosome