InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDEM1

Summary

InnateDB Protein

IDBP-14542.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDEM1

Protein Name

ER degradation enhancer, mannosidase alpha-like 1

Synonyms

EDEM;

Species

Homo sapiens

Ensembl Protein

ENSP00000256497

InnateDB Gene

IDBG-14540 (EDEM1)

Protein Structure

UniProt Annotation

Function

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity. {ECO:0000269PubMed:12610306, ECO:0000269PubMed:19524542, ECO:0000269PubMed:19934218}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19934218}; Single-pass type II membrane protein {ECO:0000269PubMed:19934218}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0051787	misfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process