InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: C8g

Summary

InnateDB Protein

IDBP-146092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C8g

Protein Name

complement component 8, gamma polypeptide

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041855

InnateDB Gene

IDBG-146088 (C8g)

Protein Structure

UniProt Annotation

Function

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001848	complement binding
GO:0019841	retinol binding
GO:0032403	protein complex binding

Biological Process

GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0019835	cytolysis

Cellular Component

GO:0005576	extracellular region
GO:0005579	membrane attack complex
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle