InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rev1

Summary

InnateDB Protein

IDBP-146764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rev1

Protein Name

REV1 homolog (S. cerevisiae)

Synonyms

1110027I23Rik; AU022044; Rev1l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027251

InnateDB Gene

IDBG-146762 (Rev1)

Protein Structure

UniProt Annotation

Function

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269PubMed:11711549}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11711549}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0016779	nucleotidyltransferase activity
GO:0017125	deoxycytidyl transferase activity

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair
GO:0009411	response to UV
GO:0042276	error-prone translesion synthesis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1929074

InterPro

IPR001126 DNA-repair protein, UmuC-like
IPR001357 BRCT domain
IPR012112 DNA repair protein, Rev1
IPR017961 DNA polymerase, Y-family, little finger domain
IPR017963 DNA-repair protein, UmuC-like, N-terminal

PFAM

PF00817
PF00533
PF12738
PF11799

PRINTS

PIRSF

PIRSF036573

SMART

SM00292

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt