InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hnrnpa2b1

Summary

InnateDB Protein

IDBP-147389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpa2b1

Protein Name

heterogeneous nuclear ribonucleoprotein A2/B1

Synonyms

9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067491

InnateDB Gene

IDBG-147385 (Hnrnpa2b1)

Protein Structure

UniProt Annotation

Function

Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform 2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0043047	single-stranded telomeric DNA binding
GO:0097157	pre-mRNA intronic binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0050658	RNA transport

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0071013	catalytic step 2 spliceosome