InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpsm1

Summary

InnateDB Protein

IDBP-148196.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpsm1

Protein Name

G-protein signalling modulator 1 (AGS3-like, C. elegans)

Synonyms

1810037C22Rik; Ags3; AW107933;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077686

InnateDB Gene

IDBG-148192 (Gpsm1)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269PubMed:16009138}.

Subcellular Localization

Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in neural progenitor cells (at protein level). {ECO:0000269PubMed:16009138}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005092	GDP-dissociation inhibitor activity
GO:0005515	protein binding
GO:0030695	GTPase regulator activity

Biological Process

GO:0007399	nervous system development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0050790	regulation of catalytic activity