InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hibadh

Summary

InnateDB Protein

IDBP-148238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hibadh

Protein Name

3-hydroxyisobutyrate dehydrogenase

Synonyms

6430402H10Rik; AI265272;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031788

InnateDB Gene

IDBG-148236 (Hibadh)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008442	3-hydroxyisobutyrate dehydrogenase activity
GO:0051287	NAD binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0006574	valine catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1889802

InterPro

IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR011548 3-hydroxyisobutyrate dehydrogenase
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF03446
PF02826
PF03807

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99L13

PhosphoSite