InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Noxo1

Summary

InnateDB Protein

IDBP-148828.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Noxo1

Protein Name

NADPH oxidase organizer 1

Synonyms

2310034C04Rik; hslt; P41NOX; P41NOXA; P41NOXB; P41NOXC; Snx28;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019464

InnateDB Gene

IDBG-148826 (Noxo1)

Protein Structure

UniProt Annotation

Function

Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269PubMed:12473664, ECO:0000269PubMed:16431374}.

Subcellular Localization

Cell membrane {ECO:0000250}. Note=Associates with the plasma membrane in a lipid-dependent manner. {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed by colon epithelial cells and to a lower extent in small intestine, uterus, stomach and testis. Expressed in different parts of the inner ear including sensory and nonsensory cell layers of the saccule, ampullae of the semicircular canals, the stria vascularis and the spiral glanglion neurons. {ECO:0000269PubMed:12473664, ECO:0000269PubMed:15949904, ECO:0000269PubMed:16431374}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016176	superoxide-generating NADPH oxidase activator activity
GO:0019899	enzyme binding
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding