Version 5.4
Mus musculus Protein: Irf2bp1
Summary
InnateDB Protein IDBP-149058.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irf2bp1
Protein Name interferon regulatory factor 2 binding protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000061234
InnateDB Gene IDBG-149056 (Irf2bp1)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2442159
InterPro IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
PFAM PF11261
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R3Y8
PhosphoSite PhosphoSite-Q8R3Y8
TrEMBL
UniProt Splice Variant
Entrez Gene 272359
UniGene Mm.401546
RefSeq NP_848872
MGI ID
MGI Symbol Irf2bp1
OMIM
CCDS CCDS20885
HPRD
IMGT
EMBL AK031834 AK087457 BC019164 BC036162
GenPept AAH19164 AAH36162 BAC27572 BAC39883

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca