InnateDB Protein
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IDBP-149083.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Plekha8
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Protein Name
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pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000098935
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InnateDB Gene
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IDBG-149079 (Plekha8)
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Protein Structure
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Function |
Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4- phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2681164
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InterPro |
IPR014830
Glycolipid transfer protein domain
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PFAM |
PF08718
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q80W71
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PhosphoSite |
PhosphoSite-Q80W71
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
231999
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UniGene |
Mm.458663
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RefSeq |
NP_001001335
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MGI ID |
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MGI Symbol |
Plekha8
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OMIM |
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CCDS |
CCDS39491
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HPRD |
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IMGT |
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EMBL |
AC084800
BB865855
BC052360
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GenPept |
AAH52360
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