InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fez1

Summary

InnateDB Protein

IDBP-149602.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fez1

Protein Name

fasciculation and elongation protein zeta 1 (zygin I)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034630

InnateDB Gene

IDBG-149600 (Fez1)

Protein Structure

UniProt Annotation

Function

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma- tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0043015	gamma-tubulin binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006810	transport
GO:0010976	positive regulation of neuron projection development
GO:0045666	positive regulation of neuron differentiation
GO:0051654	establishment of mitochondrion localization
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0030424	axon
GO:0030425	dendrite
GO:0042995	cell projection