InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRGAP3

Summary

InnateDB Protein

IDBP-15050.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRGAP3

Protein Name

SLIT-ROBO Rho GTPase activating protein 3

Synonyms

ARHGAP14; MEGAP; SRGAP2; WRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000373347

InnateDB Gene

IDBG-15048 (SRGAP3)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269PubMed:12195014, ECO:0000269PubMed:12447388}.

Subcellular Localization

Disease Associations

Note=A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25).

Tissue Specificity

Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain. {ECO:0000269PubMed:12195014, ECO:0000269PubMed:12447388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001060 FCH domain
IPR001452 SH3 domain
IPR008936 Rho GTPase activation protein
IPR011511 Variant SH3 domain

PFAM

PF00620
PF00611
PF00018
PF14604
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00324
SM00055
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt