Version 5.4
Mus musculus Protein: Nus1
Summary
InnateDB Protein IDBP-151170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nus1
Protein Name nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
Synonyms 1600027K07Rik; AU019165; AW538011; BC003223; D10Ertd438e;
Species Mus musculus
Ensembl Protein ENSMUSP00000023830
InnateDB Gene IDBG-151166 (Nus1)
Protein Structure
UniProt Annotation
Function Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (By similarity). {ECO:0000250}.Essential component of the dolichol monophosphate (Dol- P) biosynthetic machinery. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in heart, liver, kidney and pancreas. {ECO:0000269PubMed:16835300}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0001525 angiogenesis
GO:0006486 protein glycosylation
GO:0008152 metabolic process
GO:0030154 cell differentiation
GO:0032367 intracellular cholesterol transport
GO:0055092 sterol homeostasis
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1196365
InterPro IPR001441 Decaprenyl diphosphate synthase-like
PFAM PF01255
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99LJ8
PhosphoSite PhosphoSite-
TrEMBL E0CXB8
UniProt Splice Variant
Entrez Gene 52014
UniGene Mm.420368
RefSeq NP_084526
MGI ID
MGI Symbol Nus1
OMIM
CCDS CCDS23841
HPRD
IMGT
EMBL AC153526 AK155620 AK167741 AK167939 BC003223 BC018372
GenPept AAH03223 AAH18372 BAE33349 BAE39779 BAE39943

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca