InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asah1

Summary

InnateDB Protein

IDBP-151211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asah1

Protein Name

N-acylsphingosine amidohydrolase 1

Synonyms

2310081N20Rik; AC; Asah;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034000

InnateDB Gene

IDBG-151209 (Asah1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017040	ceramidase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0010033	response to organic substance
GO:0030324	lung development

Cellular Component

GO:0005764	lysosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1277124

InterPro

IPR016699 Acid ceramidase-like
IPR029055 Nucleophile aminohydrolases, N-terminal
IPR029132 Choloylglycine hydrolase/NAAA C-terminal

PFAM

PF02275

PRINTS

PIRSF

PIRSF017632

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WV54

PhosphoSite

PhosphoSite-Q9WV54

TrEMBL

Q78P93

UniProt Splice Variant

Entrez Gene

11886

UniGene

Mm.392205

RefSeq

NP_062708

MGI ID

MGI Symbol

Asah1

OMIM

CCDS

CCDS22262

HPRD

IMGT

EMBL

AF157500 AF352179 AK075666 AK075919 AK077721 AK090314 AK151478 AK166757 AY028080 BC003204 CH466554

GenPept

AAD39551 AAH03204 AAK21979 AAK39512 BAC35884 BAC36053 BAC36980 BAC41166 BAE30433 BAE38998 EDL35519