Version 5.4
Homo sapiens Protein: ZMIZ2
Summary
InnateDB Protein IDBP-15132.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZMIZ2
Protein Name zinc finger, MIZ-type containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265346
InnateDB Gene IDBG-15128 (ZMIZ2)
Protein Structure
UniProt Annotation
Function Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors. {ECO:0000269PubMed:16051670}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16051670, ECO:0000269PubMed:9853615}. Note=Detected at replication foci throughout S phase.
Disease Associations
Tissue Specificity Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary. {ECO:0000269PubMed:16051670}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0043596 nuclear replication fork
Protein Structure and Domains
PDB ID
InterPro IPR004181 Zinc finger, MIZ-type
PFAM PF02891
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NF64
PhosphoSite PhosphoSite-Q8NF64
TrEMBL C9JDA5
UniProt Splice Variant
Entrez Gene 83637
UniGene Hs.77978
RefSeq NP_777589
HUGO HGNC:22229
OMIM 611196
CCDS CCDS43577
HPRD 13225
IMGT
EMBL AB015330 AB067473 AC004859 AC013436 AK090415 AK090841 AL136572 AL831933 AY426594 BC021924 BC110435 CH236960 CH471128
GenPept AAH21924 AAI10436 AAP22368 AAR85526 BAA34789 BAB67779 BAC03396 BAG52237 CAB66507 CAH56269 EAL23750 EAW61083 EAW61084 EAW61085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca