Version 5.4
Mus musculus Protein: 1110054O05Rik
Summary
InnateDB Protein IDBP-151699.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol 1110054O05Rik
Protein Name RIKEN cDNA 1110054O05 gene
Synonyms 1110054O05Rik; 2610312O17Rik; AA399876; Ssbip1;
Species Mus musculus
Ensembl Protein ENSMUSP00000092673
InnateDB Gene IDBG-151697 (1110054O05Rik)
Protein Structure
UniProt Annotation
Function Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination- dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Localizes to nuclear foci following DNA damage. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010212 response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0070876 SOSS complex
Protein Structure and Domains
PDB ID MGI:1913459
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TXT3
PhosphoSite PhosphoSite-
TrEMBL Z4YLT1
UniProt Splice Variant
Entrez Gene 66209
UniGene Mm.51988
RefSeq NP_001013595
MGI ID
MGI Symbol Inip
OMIM
CCDS CCDS18225
HPRD
IMGT
EMBL AK004256 AK159116 AK169537 AL806512 AL929501 BC116204 BC116205 CH466565
GenPept AAI16205 AAI16206 BAC25075 BAE34832 BAE41217 CAM21912 CAM21913 CAM21914 EDL02202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca