InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr4

Summary

InnateDB Protein

IDBP-152684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr4

Protein Name

5 hydroxytryptamine (serotonin) receptor 4

Synonyms

5-HT-4; 5-HT<4L>; 5-HT4; 5HTR4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027560

InnateDB Gene

IDBG-152682 (Htr4)

Protein Structure

UniProt Annotation

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0008284	positive regulation of cell proliferation
GO:0032098	regulation of appetite