InnateDB Protein
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IDBP-153307.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sfxn1
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Protein Name
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sideroflexin 1
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Synonyms
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2810002O05Rik; A930015P12Rik; f;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021930
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InnateDB Gene
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IDBG-153305 (Sfxn1)
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Protein Structure
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Function |
Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.
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Subcellular Localization |
Mitochondrion membrane; Multi-pass membrane protein.
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Disease Associations |
Note=Defects in Sfxn1 are the cause of a transitory hypochromic, microcytic anemia characterized by a large number of siderocytes containing non-heme iron granules. The anemia begins at 12 dpc, is most intense at 15 dpc and is still severe at birth, but disappears by 2 weeks of age. Mutant adults are no longer anemic, but they have an impaired response to hemopoietic stress. Most homozygotes also have flexed tails and a belly spot. {ECO:0000269PubMed:11274051}.
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Tissue Specificity |
Widely expressed, with highest expression in kidney and liver. {ECO:0000269PubMed:11274051}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
33 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003674
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molecular_function
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GO:0008324
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cation transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2137677
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InterPro |
IPR004686
Tricarboxylate/iron carrier
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PFAM |
PF03820
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99JR1
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PhosphoSite |
PhosphoSite-Q99JR1
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TrEMBL |
Q8BPC9
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UniProt Splice Variant |
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Entrez Gene |
14057
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UniGene |
Mm.134191
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RefSeq |
NP_081600
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MGI ID |
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MGI Symbol |
Sfxn1
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OMIM |
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CCDS |
CCDS26525
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HPRD |
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IMGT |
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EMBL |
AF325260
AK012650
AK076205
AK151110
BC005743
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GenPept |
AAH05743
AAK39428
BAC36253
BAE30120
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