InnateDB Protein
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IDBP-15338.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RAD1
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Protein Name
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RAD1 homolog (S. pombe)
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Synonyms
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HRAD1; REC1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000371469
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InnateDB Gene
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IDBG-15336 (RAD1)
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Protein Structure
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Function |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity. {ECO:0000269PubMed:21659603, ECO:0000269PubMed:9660799}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:9716408}.
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Disease Associations |
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Tissue Specificity |
Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level). {ECO:0000269PubMed:9716408}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003011
Cell cycle checkpoint protein, Rad1
IPR003021
Rad1/Rec1/Rad17
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PFAM |
PF02144
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PRINTS |
PR01246
PR01245
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O60671
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PhosphoSite |
PhosphoSite-O60671
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TrEMBL |
A0A024R045
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UniProt Splice Variant |
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Entrez Gene |
5810
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UniGene |
Hs.713947
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RefSeq |
NP_002844
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HUGO |
HGNC:9806
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OMIM |
603153
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CCDS |
CCDS3905
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HPRD |
04400
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IMGT |
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EMBL |
AB183821
AB183822
AF011905
AF030933
AF058392
AF073524
AF074717
AF076841
AF084512
AF084513
AF090170
AJ004974
AJ004975
AK002112
BC006837
BC009804
BC037857
BT006908
CH471119
DQ451401
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GenPept |
AAC14138
AAC27243
AAC35549
AAC35550
AAC95427
AAC95466
AAC95523
AAC95603
AAC98093
AAH06837
AAH09804
AAH37857
AAP35554
ABD96829
BAD86789
BAD86790
BAG51017
CAA06248
CAA06249
EAW55904
EAW55906
EAW55907
EAW55908
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