InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcd1

Summary

InnateDB Protein

IDBP-153432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcd1

Protein Name

ATP-binding cassette, sub-family D (ALD), member 1

Synonyms

Ald; Aldgh; ALDP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002084

InnateDB Gene

IDBG-153430 (Abcd1)

Protein Structure

UniProt Annotation

Function

Probable transporter. Could be involved in the import of VLCFA-CoA synthetase into the peroxisomal membrane.

Subcellular Localization

Peroxisome membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed at low levels with higher levels in heart, lung, intestine and spleen than in skeletal muscle, brain, liver and kidney. {ECO:0000269PubMed:10504404}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005325	peroxisomal fatty-acyl-CoA transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019899	enzyme binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006810	transport
GO:0015910	peroxisomal long-chain fatty acid import
GO:0042758	long-chain fatty acid catabolic process
GO:0042760	very long-chain fatty acid catabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1349215

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005283 Peroxysomal long chain fatty acyl transporter
IPR010509 Peroxisomal fatty acyl CoA transporter, transmembrane domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF06472

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48410