InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPI1

Summary

InnateDB Protein

IDBP-15362.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPI1

Protein Name

triosephosphate isomerase 1

Synonyms

HEL-S-49; TIM; TPI; TPID;

Species

Homo sapiens

Ensembl Protein

ENSP00000229270

InnateDB Gene

IDBG-15360 (TPI1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Triosephosphate isomerase deficiency (TPID) [MIM:615512]: An autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy. {ECO:0000269PubMed:2876430, ECO:0000269PubMed:8503454, ECO:0000269PubMed:8571957, ECO:0000269PubMed:9338582, ECO:0000269Ref.31}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004807	triose-phosphate isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006098	pentose-phosphate shunt
GO:0007275	multicellular organismal development
GO:0008152	metabolic process
GO:0019682	glyceraldehyde-3-phosphate metabolic process
GO:0044281	small molecule metabolic process