InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPM1

Summary

InnateDB Protein

IDBP-15414.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPM1

Protein Name

tropomyosin 1 (alpha)

Synonyms

C15orf13; CMD1Y; CMH3; HTM-alpha; LVNC9; TMSA;

Species

Homo sapiens

Ensembl Protein

ENSP00000334624

InnateDB Gene

IDBG-15400 (TPM1)

Protein Structure

UniProt Annotation

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Cardiomyopathy, familial hypertrophic 3 (CMH3) [MIM:115196]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269PubMed:12974739, ECO:0000269PubMed:7898523, ECO:0000269PubMed:8205619, ECO:0000269PubMed:8523464, ECO:0000269PubMed:9822100}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cardiomyopathy, dilated 1Y (CMD1Y) [MIM:611878]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:11273725}. Note=The disease is caused by mutations affecting the gene represented in this entry.Left ventricular non-compaction 9 (LVNC9) [MIM:611878]: A disease due to an arrest of myocardial morphogenesis. It is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies. {ECO:0000269PubMed:21551322}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. {ECO:0000269PubMed:15249230, ECO:0000269Ref.15}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0008092	cytoskeletal protein binding
GO:0008307	structural constituent of muscle

Biological Process

GO:0003065	positive regulation of heart rate by epinephrine
GO:0006928	cellular component movement
GO:0006936	muscle contraction
GO:0006937	regulation of muscle contraction
GO:0007010	cytoskeleton organization
GO:0008016	regulation of heart contraction
GO:0030049	muscle filament sliding
GO:0030336	negative regulation of cell migration
GO:0031529	ruffle organization
GO:0032781	positive regulation of ATPase activity
GO:0034614	cellular response to reactive oxygen species
GO:0042060	wound healing
GO:0045214	sarcomere organization
GO:0045785	positive regulation of cell adhesion
GO:0051496	positive regulation of stress fiber assembly
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0001725	stress fiber
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005862	muscle thin filament tropomyosin
GO:0030017	sarcomere
GO:0032059	bleb
GO:0032587	ruffle membrane