Version 5.4
Mus musculus Protein: Irf2
Summary
InnateDB Protein IDBP-154371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irf2
Protein Name interferon regulatory factor 2
Synonyms 9830146E22Rik; AI646973; Irf-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000034041
InnateDB Gene IDBG-154369 (Irf2)
Protein Structure
UniProt Annotation
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 5 [view]
Protein-DNA 17 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID MGI:96591
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
IPR017431 Interferon regulatory factor-1/2
PFAM PF00605
PRINTS PR00267
PIRSF PIRSF038196
SMART SM00348
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23906
PhosphoSite PhosphoSite-P23906
TrEMBL Q3U2Z2
UniProt Splice Variant
Entrez Gene 16363
UniGene Mm.402627
RefSeq NP_032417
MGI ID 2IRF
MGI Symbol Irf2
OMIM
CCDS CCDS22295
HPRD
IMGT
EMBL AK155025 CH466554 J03168
GenPept AAA39333 BAE32998 EDL35583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca