Version 5.4
Mus musculus Protein: Dlgap5
Summary
InnateDB Protein IDBP-154461.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlgap5
Protein Name discs, large (Drosophila) homolog-associated protein 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000040416
InnateDB Gene IDBG-154459 (Dlgap5)
Protein Structure
UniProt Annotation
Function Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells (By similarity). {ECO:0000250UniProtKB:Q15398}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at low levels in normal resting liver. Up-regulated in regenerating liver after partial hepatectomy. {ECO:0000269PubMed:12527899}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
Biological Process
GO:0000087 mitotic M phase
GO:0007267 cell-cell signaling
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0031616 spindle pole centrosome
Protein Structure and Domains
PDB ID MGI:2183453
InterPro IPR005026 Guanylate-kinase-associated protein
PFAM PF03359
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4R9
PhosphoSite PhosphoSite-Q8K4R9
TrEMBL
UniProt Splice Variant
Entrez Gene 218977
UniGene Mm.490777
RefSeq NP_653136
MGI ID
MGI Symbol Dlgap5
OMIM
CCDS CCDS26987
HPRD
IMGT
EMBL AB076696 AK036384 AK085882 AK129032 BC043924 BC058087
GenPept AAH43924 AAH58087 BAB97377 BAC29405 BAC39560 BAC97842

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca